The antiserum was produced against synthesized peptide derived from human p47 phox around the phosphorylation site of Ser370. AA range:341-390

Phospho-p47-phox (S370) Polyclonal Antibody detects endogenous levels of p47-phox protein only when phosphorylated at S370.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RPsAD

NCF1

Neutrophil cytosol factor 1

NCF1 ;
NOXO2 ;
SH3PXD1A ;
Neutrophil cytosol factor 1 ;
NCF-1 ;
47 kDa autosomal chronic granulomatous disease protein ;
47 kDa neutrophil oxidase factor ;
NCF-47K ;
Neutrophil NADPH oxidase factor 1 ;
Nox organizer 2 ;
Nox-organizing protein 2 ;
SH3

The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008],

Disease:Defects in NCF1 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 1 (CGD1) [MIM:233700]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.,Function:NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).,online information:NCF1 deficiency database,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with NOXA1.,

Cytoplasm, cytosol . Membrane ; Peripheral membrane protein ; Cytoplasmic side .

Detected in peripheral blood monocytes and neutrophils (at protein level).

>>Chemokine signaling pathway ;
>>Phagosome ;
>>Osteoclast differentiation ;
>>Neutrophil extracellular trap formation ;
>>Fc gamma R-mediated phagocytosis ;
>>Leukocyte transendothelial migration ;
>>Prion disease ;
>>Leishmaniasis ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Diabetic cardiomyopathy ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis