Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors . Plays an essential role in phototransduction, by mediating cGMP replenishment (By similarity). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity).
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细胞定位:
Photoreceptor outer segment membrane ; Single-pass type I membrane protein .
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组织表达:
Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells.