PAN2 Rabbit pAb
-YN6014
主要信息
Target
PAN2
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
132kD (Calculated)
Conjugate/Modification
Unmodified
货号: YN6014
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of PAN2 at Human, Mouse,Rat
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
132kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human PAN2
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特异性:
This antibody detects endogenous levels of PAN2 at Human, Mouse,Rat
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基因名称:
PAN2 KIAA0710 USP52
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蛋白名称:
PAB-dependent poly(A)-specific ribonuclease subunit 2 (hPan2) (Inactive ubiquitin carboxyl-terminal hydrolase 52)
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功能:
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
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细胞定位:
Cytoplasm . Cytoplasm, P-body . Nucleus . Shuttles between nucleus and cytoplasm. .
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文献引用（{{totalcount}}）
货号: YN6014
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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