Synthesized peptide derived from human CREST

This antibody detects endogenous levels of CREST at Human, Mouse,Rat

SS18L1 CREST KIAA0693

Calcium-responsive transactivator (SS18-like protein 1) (SYT homolog 1)

Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).

Nucleus . Chromosome, centromere, kinetochore . Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity). .