BRD7 Rabbit pAb
-YN5794
主要信息
Target
BRD7
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB
MW
72kD (Calculated)
Conjugate/Modification
Unmodified
货号: YN5794
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of BRD7 at Human, Mouse
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
72kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human BRD7. AA range:384-484
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特异性:
This antibody detects endogenous levels of BRD7 at Human, Mouse
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基因名称:
BRD7 BP75 CELTIX1
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蛋白名称:
Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1)
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功能:
Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity) . Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters , leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac) . Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382' , and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.
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细胞定位:
[Isoform 2]: Nucleus.
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信号通路
文献引用（{{totalcount}}）
货号: YN5794
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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