CALHM1 Rabbit pAb
-YN5650
主要信息
Target
CALHM1
Host Species
Rabbit
Reactivity
Human, Rat
Applications
WB, IHC, IF
MW
40kD (Observed)
Conjugate/Modification
Unmodified
货号: YN5650
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
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详细信息
推荐稀释比
WB 1:500-1000; IHC 1:200-500; IF 1:50-200
组成
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
特异性
The antibody detects endogenous CALHM1 protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
实测条带
40kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthetic Peptide of CALHM1 AA range: 204-254
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特异性:
The antibody detects endogenous CALHM1 protein.
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基因名称:
CALHM1
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蛋白名称:
Calcium homeostasis modulator protein 1
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别名:
Calcium homeostasis modulator protein 1 ;
Protein FAM26C
Protein FAM26C
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背景:
calcium homeostasis modulator 1(CALHM1) Homo sapiens This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010],
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功能:
Function:May be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner.,polymorphism:Leu-86 causes a dysregulation of Ca(2+) homeostasis and amyloid precursor protein (APP) metabolism, and may be a risk factor for the development of Alzheimer's disease.,similarity:Belongs to the FAM26 family.,subcellular location:Colocalizes with HSPA5 at the endoplasmic reticulum.,subunit:Homooligomer; homomultimerized to form dimeric and possibly tetrameric structures.,tissue specificity:Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells.,
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细胞定位:
Cell membrane; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein . Colocalizes with HSPA5 at the endoplasmic reticulum (PubMed:18585350). Localizes to the basolateral membrane of epithelial cells including taste cells (By similarity). .
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研究领域:
>>Taste transduction
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货号: YN5650
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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