Synthesized peptide derived from human TRY6 AA range: 21-71

This antibody detects endogenous levels of TRY6 at Human

TRY6 T6

TRY6

Although this locus appears to encode a protein similar to trypsinogen, the locus is thought to be a transcribed pseudogene. ESTs support its transcription, but expression of its predicted protein has not been observed. Its predicted protein sequence differs significantly from the known functional trypsinogens, including a different amino acid at the conserved residue 122 which is important for autolysis. This pseudogene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008],

Catalytic activity:Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.,Caution:Tyr-154 was proposed to be phosphorylated (PubMed:8683601) but it has been shown (PubMed:17087724) to be sulfated instead. Phosphate and sulfate groups are similar in mass and size, and this can lead to erroneous interpretation of the results.,cofactor:Binds 1 calcium ion per subunit.,Disease:Defects in PRSS1 are a cause of hereditary pancreatitis (HPC) [MIM:167800]; also known as chronic pancreatitis (CP). HPC is an autosomal dominant disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks.,Function:Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.,mass spectrometry: PubMed:8683601,PTM:Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,

Secreted .

Overexpressed in metastasing in non small cell lung tumors, leading to an enhanced cell migration.