Synthesized peptide derived from human GPT AA range: 209-259

This antibody detects endogenous levels of GPT at Human/Mouse

DPAGT1 DPAGT2

GPT

The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008],

Catalytic activity:UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.,Disease:Defects in DPAGT1 are the cause of congenital disorder of glycosylation type 1J (CDG1J) [MIM:608093]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.,Function:Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides.,online information:GlycoGene database,online information:UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 4 family.,

Endoplasmic reticulum membrane; Multi-pass membrane protein .

>>N-Glycan biosynthesis ;
>>Metabolic pathways