PBIP1 Rabbit pAb
-YN3553
主要信息
Target
PBIP1
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
80kD (Calculated)
Conjugate/Modification
Unmodified
货号: YN3553
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of PBIP1 at Human/Mouse/Rat
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
80kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human PBIP1 AA range: 585-635
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特异性:
This antibody detects endogenous levels of PBIP1 at Human/Mouse/Rat
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基因名称:
PBXIP1 HPIP
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蛋白名称:
PBIP1
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背景:
The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015],
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功能:
Domain:Association to the cytoskeleton through a N-terminal leucine rich-domain (AA 190-218).,Domain:The C-terminal domain (AA 443-731) contains a nuclear export signal.,Function:Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.,subcellular location:Shuttles between the nucleus and the cytosol. Mainly localized in the cytoplasm, associated with microtubules. Detected in small amounts in the nucleus.,subunit:Interacts with ESR1, PBX1, PBX2 and PBX3.,tissue specificity:Expressed in early hematopietic precursors.,
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细胞定位:
Cytoplasm, cytoskeleton . Nucleus . Shuttles between the nucleus and the cytosol (PubMed:12360403). Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160).
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组织表达:
Expressed in early hematopoietic precursors.
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文献引用（{{totalcount}}）
货号: YN3553
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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