TLE3 Rabbit pAb
-YN3385
主要信息
Target
TLE3
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
85kD (Observed)
Conjugate/Modification
Unmodified
货号: YN3385
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of TLE3 at Human/Mouse/Rat
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
85kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human TLE3 AA range: 257-307
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特异性:
This antibody detects endogenous levels of TLE3 at Human/Mouse/Rat
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基因名称:
TLE3 KIAA1547
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蛋白名称:
TLE3
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别名:
Transducin-like enhancer protein 3 ;
Enhancer of split groucho-like protein 3 ;
ESG3 ;
Enhancer of split groucho-like protein 3 ;
ESG3 ;
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背景:
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013],
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功能:
Alternative products:Experimental confirmation may be lacking for some isoforms,Function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.,similarity:Belongs to the WD repeat Groucho/TLE family.,similarity:Contains 7 WD repeats.,subunit:Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1 and TCF7L2 (By similarity). Binds FOXA2.,tissue specificity:Placenta and lung.,
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细胞定位:
Nucleus.
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组织表达:
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研究领域:
>>Wnt signaling pathway ;
>>Notch signaling pathway
>>Notch signaling pathway
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信号通路
文献引用（{{totalcount}}）
货号: YN3385
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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