Synthesized peptide derived from human TRI37 AA range: 315-365

This antibody detects endogenous levels of TRI37 at Human/Mouse

TRIM37 KIAA0898 MUL POB1

TRI37

E3 ubiquitin-protein ligase TRIM37 ;
Mulibrey nanism protein ;
Tripartite motif-containing protein 37 ;

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. [provided by RefSeq, Mar 2016],

Disease:Defects in TRIM37 are the cause of mulibrey nanism (MUL) [MIM:253250]; also called muscle-liver-brain-eye nanism. Mulibrey nanism is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common.,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 MATH domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Found in vesicles of the peroxisome.,tissue specificity:Ubiquitous.,

Cytoplasm, perinuclear region . Peroxisome . Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. .

Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976).

>>Ubiquitin mediated proteolysis