Synthesized peptide derived from human PI51A AA range: 270-320

This antibody detects endogenous levels of PI51A at Human/Mouse

PIP5K1A

PI51A

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha ;
PIP5K1-alpha ;
PtdIns ;
4 ;
P-5-kinase 1 alpha ;
68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha ;
Phosphatidylinositol 4-phosphate 5-kinase type I alpha ;
PIP5KIalpha ;

Catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.,Function:Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2.,similarity:Contains 1 PI5K domain.,subcellular location:Associated with the plasma membrane and with internal membranes. Associated with Golgi stacks (By similarity). Detected on RAC1-induced plasma membrane ruffles, and on membrane ruffles induced by platelet-derived growth factor.,subunit:Interacts with ARF1, RAC1, PLD1, PLD2 and JUB.,tissue specificity:Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver.,

Cell membrane . Cytoplasm . Nucleus . Nucleus speckle . Cell projection, ruffle . Cell projection, lamellipodium . Colocalizes with RAC1 at actin-rich membrane ruffles (PubMed:20660631). Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs (PubMed:18288197). .

Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver.

>>Inositol phosphate metabolism ;
>>Metabolic pathways ;
>>Phosphatidylinositol signaling system ;
>>Phospholipase D signaling pathway ;
>>Endocytosis ;
>>Focal adhesion ;
>>Fc gamma R-mediated phagocytosis ;
>>Regulation of actin cytoskeleton ;
>>Yersinia infection ;
>>Choline metabolism in cancer