TNR18 Rabbit pAb
-YN2862
主要信息
Target
TNR18
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA
MW
26kD (Observed)
Conjugate/Modification
Unmodified
货号: YN2862
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
特异性
TNR18 Polyclonal Antibody detects endogenous levels of protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
26kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from part region of human protein
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特异性:
TNR18 Polyclonal Antibody detects endogenous levels of protein.
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基因名称:
TNFRSF18 AITR GITR UNQ319/PRO364
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蛋白名称:
Tumor necrosis factor receptor superfamily member 18 (Activation-inducible TNFR family receptor) (Glucocorticoid-induced TNFR-related protein) (CD antigen CD357)
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背景:
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011],
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功能:
Function:Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.,induction:Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA.,tissue specificity:Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.,
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细胞定位:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
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组织表达:
Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.
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研究领域:
>>Cytokine-cytokine receptor interaction
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文献引用（{{totalcount}}）
货号: YN2862
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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