This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010],
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功能:
similarity:Contains 2 UBA domains.,tissue specificity:Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas.,
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细胞定位:
Cytoplasm, cytosol . Endosome . Predominantly cytosolic (PubMed:21757351). Recruited to endosomes as part of the ESCRT-I complex (PubMed:21757351). .
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组织表达:
Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas.