Synthesized peptide derived from part region of human protein

SCNAA Polyclonal Antibody detects endogenous levels of protein.

SCN10A

Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (hPN3) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8)

The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014],

Domain:The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.,Function:This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms.,PTM:Ubiquitinated by NEDD4L; which promotes its endocytosis.,similarity:Belongs to the sodium channel family.,similarity:Contains 1 IQ domain.,subcellular location:It can be translocated to the extracellular membrane through association with S100A10.,subunit:The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B. Found in a number of complexes with PRX, TCTEL1 and PDZD2. Interacts with proteins such as FSTL1, PRX, TCTEL1, PDZD2, S100A10 and many others (By similarity). Interacts with NEDD4 and NEDD4L.,tissue specificity:Expressed in the dorsal root ganglia and sciatic nerve.,

Cell membrane ; Multi-pass membrane protein . It can be translocated to the cell membrane through association with S100A10. .

Expressed in the dorsal root ganglia and sciatic nerve.