Synthesized peptide derived from human protein . at AA range: 180-260

ADA19 Polyclonal Antibody detects endogenous levels of protein.

ADAM19 MLTNB FKSG34

Disintegrin and metalloproteinase domain-containing protein 19 (ADAM 19) (Meltrin-beta) (Metalloprotease and disintegrin dendritic antigen marker) (MADDAM)

ADAM metallopeptidase domain 19(ADAM19) Homo sapiens This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013],

cofactor:Binds 1 zinc ion per subunit.,Domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,Function:Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone.,induction:By 1,25(OH)2VD3 in monocytes.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase M12B domain.,subunit:Interacts with SH3PXD2A.,tissue specificity:Expressed in many normal organ tissues and several cancer cell lines.,

Membrane; Single-pass type I membrane protein.