Endogenous

IRAG2;JAW1;LRMP

Inositol 1,4,5-triphosphate receptor associated 2;Lymphoid-restricted membrane protein;Protein Jaw1; [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2]

IRAG2 ;
JAW1 ;
LRMP ;
Inositol 1,4,5-triphosphate receptor associated 2 ;
Lymphoid-restricted membrane protein ;
Protein Jaw1 ;
[Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] ;

The protein encode dby this gene is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. The protein is localized to the cytoplasmic face of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]

Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}.

[Processed inositol 1,4,5-triphosphate receptor associated 2]: Cytoplasm.; Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Note=Colocalized with ITPR3 on the endoplasmic reticulum membrane..

Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in the cerebral cortex, epithelial cells in tonsil, adrenal glands, zymogen-producing cells in the stomach and epithelial cells in seminal vesicles. {ECO:0000269|PubMed:16739114, ECO:0000269|PubMed:8021504}.