Endogenous

EGR1

Early growth response protein 1

EGR1 ;
KROX24 ;
ZNF225 ;
Early growth response protein 1 ;
EGR-1 ;
AT225 ;
Nerve growth factor-induced protein A ;
NGFI-A ;
Transcription factor ETR103 ;
Transcription factor Zif268 ;
Zinc finger protein 225 ;
Zinc finger protein Krox-24

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014],

Function:Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.,induction:By growth factors.,similarity:Belongs to the EGR C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,

Cytoplasm, Nucleus

Detected in neutrophils (at protein level).

>>Apelin signaling pathway ;
>>GnRH signaling pathway ;
>>Parathyroid hormone synthesis, secretion and action ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Prion disease ;
>>Human T-cell leukemia virus 1 infection