Endogenous

CAMK2B CAM2 CAMK2 CAMKB

Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)

The product of this gene belongs toThe serine/threonine protein kinase family and toThe Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells,The enzyme is composed of four different chains: alpha, beta, gamma, and delta.The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],

Alternative products:The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms,Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,Function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ.,tissue specificity:Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain.,

Cytoplasm

Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.

>>ErbB signaling pathway ;
>>Calcium signaling pathway ;
>>cAMP signaling pathway ;
>>HIF-1 signaling pathway ;
>>Oocyte meiosis ;
>>Necroptosis ;
>>Adrenergic signaling in cardiomyocytes ;
>>Wnt signaling pathway ;
>>Axon guidance ;
>>Circadian entrainment ;
>>Long-term potentiation ;
>>Neurotrophin signaling pathway ;
>>Cholinergic synapse ;
>>Dopaminergic synapse ;
>>Olfactory transduction ;
>>Inflammatory mediator regulation of TRP channels ;
>>Insulin secretion ;
>>GnRH signaling pathway ;
>>Melanogenesis ;
>>Oxytocin signaling pathway ;
>>Glucagon signaling pathway ;
>>Aldosterone synthesis and secretion ;
>>Cushing syndrome ;
>>Gastric acid secretion ;
>>Parkinson disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Amphetamine addiction ;
>>Tuberculosis ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>Glioma ;
>>Diabetic cardiomyopathy ;
>>Lipid and atherosclerosis