Synthesized peptide derived from human p57kip2 AA range: 200-316

The antibody can specifically recognize human p57kip2 protein.

CDKN1C KIP2

Beckwith Wiedemann syndrome;BWCR;BWS;CDKI;CDKN 1C;CDKN1C;CDN1C_HUMAN;Cyclin dependent kinase inhibitor 1C;Cyclin dependent kinase inhibitor p57;Cyclin-dependent kinase inhibitor 1C;Cyclin-dependent kinase inhibitor p57;KIP 2;KIP2;p57;p57 Kip 2;p57KIP2;WBS

Beckwith Wiedemann syndrome ;
BWCR ;
BWS ;
CDKI ;
CDKN 1C ;
CDKN1C ;
CDN1C_HUMAN ;
Cyclin dependent kinase inhibitor 1C ;
Cyclin dependent kinase inhibitor p57 ;
Cyclin-dependent kinase inhibitor 1C ;
Cyclin-dependent kinase inhibitor p57 ;
KIP 2 ;
KIP2 ;
p57 ;
p57 Kip 2 ;
p57KIP2 ;
WBS

This gene is imprinted , with preferential expression of the maternal allele. The encoded protein is a tight-binding , strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome , suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq , Oct 2010] ,

Disease:Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele) , pre- and postnatal overgrowth , and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors. ,Disease:Defects in CDKN1C are involved in tumor formation. ,Function:Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2 , cyclin D2-CDK4 , and cyclin A-CDK2) and , to lesser extent , of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. ,similarity:Belongs to the CDI family. ,tissue specificity:Expressed in the heart , brain , lung , skeletal muscle , kidney , pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver. ,

Nuclear

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