S100 (ABT094) Mouse mAb (Ready to Use)
-YM6987R
主要信息
Target
S100
Host Species
Mouse
Reactivity
Human, Mouse, Rat
Applications
IHC
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
Ready to use for IHC
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
特异性
The antibody can specifically recognize human S100B protein, and has a weak reaction with S100A1, but no cross reaction with S100A4 or S100A6.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
2°C to 8°C/1 year,Ship by ice bag
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT094
同种型
IgG2a, Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human S100 AA range: 2-92
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特异性:
The antibody can specifically recognize human S100B protein, and has a weak reaction with S100A1, but no cross reaction with S100A4 or S100A6.
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基因名称:
S100B
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蛋白名称:
S100
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别名:
Protein S100-B ;
S-100 protein beta chain ;
S-100 protein subunit beta ;
S100 calcium-binding protein B ;
S-100 protein beta chain ;
S-100 protein subunit beta ;
S100 calcium-binding protein B ;
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背景:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells , and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however , this gene is located at 21q22.3. This protein may function in Neurite extension , proliferation of melanoma cells , stimulation of Ca2+ fluxes , inhibition of PKC-mediated phosphorylation , astrocytosis and axonal proliferation , and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological , neoplastic , and other types of diseases , including Alzheimer's disease , Down's syndrome , epilepsy
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功能:
Function:Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations , especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. ,miscellaneous:In addition to metal-ion binding , this protein is involved with the regulation of protein phosphorylation in brain tissue. ,similarity:Belongs to the S-101 family. ,similarity:Contains 2 EF-hand domains. ,subunit:Dimer of either two alpha chains , or two beta chains , or one alpha and one beta chain. The S100B dimer binds two molecules of STK38 (By similarity) . The S100B dimer interacts with two molecules of CAPZA1. ,tissue specificity:Although predominant among the water-soluble brain proteins , S100 is also found in a variety of other tissues. ,
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细胞定位:
Nuclear , Cytoplasmic
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