Synthesized peptide derived from human MDR1 AA range: 600-700

The antibody can specifically recognize human MDR1 protein.

ABCB1 MDR1 PGY1

ABC20;ABCB1;ATP binding cassette, sub family B (MDR/TAP) , member 1;ATP-binding cassette sub-family B member 1;CD243;CLCS;Colchicin sensitivity;Doxorubicin resistance;GP170;MDR1;MDR1_HUMAN;Multidrug resistance 1;Multidrug resistance protein 1;P glycoprotein 1;P gp;P-glycoprotein 1;PGY1

ABC20 ;
ABCB1 ;
ATP binding cassette,sub family B ;
MDR/TAP ;
member 1 ;
ATP-binding cassette sub-family B member 1 ;
CD243 ;
CLCS ;
Colchicin sensitivity ;
Doxorubicin resistance ;
GP170 ;
MDR1 ;
MDR1_HUMAN ;
Multidrug resistance 1 ;
Multidrug resistance protein 1 ;
P glycoprotein 1 ;
P gp ;
P-glycoprotein 1 ;
PGY1 ;
P Glycoprotein

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1 , MDR/TAP , MRP , ALD , OABP , GCN20 , White) . This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq , Jul 2008] ,

Catalytic activity:ATP + H (2) O + xenobiotic (In) = ADP + phosphate + xenobiotic (Out) . ,Disease:Genetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13) [MIM:612244]. Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may involve any part of the gastrointestinal tract , but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast , in ulcerative colitis , the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin , eyes , or joints. Crohn disease and ulcerative colitis are commonly classified as autoimmune diseases. ,Function:Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. ,online information:P-glycoprotein entry ,online information:The Singapore human mutation and polymorphism database ,polymorphism:Genetic variation in ABCB1 may play a role in patients who do not respond to drug treatment. ,similarity:Belongs to the ABC transporter family. ,similarity:Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. ,similarity:Contains 2 ABC transmembrane type-1 domains. ,similarity:Contains 2 ABC transporter domains. ,tissue specificity:Expressed in liver , kidney , small intestine and brain. ,

Membranous

>>ABC transporters ;
>>Bile secretion ;
>>MicroRNAs in cancer ;
>>Gastric cancer