Synthesized peptide derived from human NKX3.1 AA range: 1-100

The antibody can specifically recognize human NKX3.1 protein.

NKX3-1 NKX3.1 NKX3A

Homeobox protein Nkx-3.1

BAPX 2 ;
BAPX2 ;
Homeobox protein NK-3 homolog A ;
Homeobox protein Nkx 3.1 ;
Homeobox protein Nkx-3.1 ;
Homeobox protein Nkx3.1 ;
NK homeobox ;
Drosophila ;
family 3 A ;
NK homeobox family 3 A ;
NK homeobox,family 3,member A ;
NK3 homeobox 1 ;
NK3 transcription factor homolog A ;
NK3 transcription factor related locus 1 ;
NKX 3 ;
Nkx 3.1 ;
NKX 3A ;
NKX3 1 ;
NKX3 ;
Nkx3-1 ;
NKX3.1 ;
Nkx3.1,mouse,homolog of ;
NKX31_HUMAN ;
NKX3A

This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq , Jan 2012] ,

Alternative products:Additional isoforms seem to exist ,Disease:NKX3-1 has been thought to be one of the target gene of the 8p21 loss of heterozygosity , common in prostate cancer , but neither disruption of the coding region of the gene , nor mutations have been found in prostate cancer. ,Function:Transcription factor , which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Could play an important role in regulating proliferation of glandular epithelium and in the formation of ducts in prostate. ,induction:By androgens and , in the LNCAP cell line , by estrogens. Androgenic control may be lost in prostate cancer cells during tumor progression from an androgen-dependent to an androgen-independent phase. ,similarity:Belongs to the NK-3 homeobox family. ,similarity:Contains 1 homeobox DNA-binding domain. ,subunit:Interacts with serum response factor (SRF) (By similarity) . Interacts with SPDEF. Interacts with WDR77. ,tissue specificity:Highly expressed in the prostate and , at a lower level , in the testis. ,

Nuclear

>>Pathways in cancer ;
>>Prostate cancer