Glypican-3 (ABT068) Mouse mAb (Ready to Use)
-YM6954R
主要信息
Target
Glypican-3
Host Species
Mouse
Reactivity
Human
Applications
IHC
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
Ready to use for IHC
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
特异性
The antibody can specifically recognize human Glypican-3 protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
2°C to 8°C/1 year,Ship by ice bag
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT068
同种型
IgG1, Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human Glypican-3(GPC3) AA range: 400-500
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特异性:
The antibody can specifically recognize human Glypican-3 protein.
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基因名称:
GPC3 OCI5
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蛋白名称:
Glypican-3 (GPC3)
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别名:
Glypican-3 ;
GTR2-2 ;
Intestinal protein OCI-5 ;
MXR7 ;
[Cleaved into: Secreted glypican-3]
GTR2-2 ;
Intestinal protein OCI-5 ;
MXR7 ;
[Cleaved into: Secreted glypican-3]
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背景:
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26 , and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome , also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Sep 2009] ,
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功能:
Disease:Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS) [MIM:312870]; also known as Simpson dysmorphia syndrome (SDYS) . SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies. ,Function:Cell surface proteoglycan that bears heparan sulfate. ,Function:Cell surface proteoglycan that bears heparan sulfate. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. ,similarity:Belongs to the glypican family. ,tissue specificity:Highly expressed in lung , liver and kidney. ,
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细胞定位:
Cytoplasmic
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组织表达:
研究领域:
>>Proteoglycans in cancer
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