IRF-4/MUM1 (ABT080) Mouse mAb
-YM6893
主要信息
Target
MUM1
Host Species
Mouse
Reactivity
Human
Applications
IHC, ELISA
MW
52kD (Calculated)
52kD (Observed)
Conjugate/Modification
Unmodified
货号: YM6893
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
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详细信息
推荐稀释比
IHC 1:200-400; ELISA 1:500-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
The antibody can specifically recognize human MUM1 protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
52kD
实测条带
52kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT080
同种型
IgG1, Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human MUM1 AA range: 350-451
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特异性:
The antibody can specifically recognize human MUM1 protein.
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基因名称:
IRF4 MUM1
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蛋白名称:
Interferon regulatory factor 4
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别名:
Interferon regulatory factor 4 ;
IRF-4 ;
Lymphocyte-specific interferon regulatory factor ;
LSIRF ;
Multiple myeloma oncogene 1 ;
NF-EM5 ;
IRF-4 ;
Lymphocyte-specific interferon regulatory factor ;
LSIRF ;
Multiple myeloma oncogene 1 ;
NF-EM5 ;
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背景:
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors , characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus , and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus , t (6;14) (p25;q32) , may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq , Aug 2010] ,
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功能:
Disease:A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t (6;14) (p25;q32) with the IgH locus. ,Function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer , together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. ,induction:Not induced by interferons. ,similarity:Belongs to the IRF family. ,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain. ,subunit:Interacts with SPIB and DEF6. ,tissue specificity:Lymphoid cells. ,
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细胞定位:
Nuclear
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组织表达:
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研究领域:
>>Th17 cell differentiation
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文献引用（{{totalcount}}）
货号: YM6893
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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