CD38 (ABT298) Mouse mAb
-YM6840
主要信息
Target
CD38
Host Species
Mouse
Reactivity
Human
Applications
IHC, IF, ELISA
MW
34kD (Calculated)
40kD (Observed)
Conjugate/Modification
Unmodified
货号: YM6840
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
IHC 1:200-400; IF 1:200-1:1000; ELISA 1:500-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
The antibody can specifically recognize human CD38 protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
34kD
实测条带
40kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT298
同种型
IgG2b, Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human CD38 AA range: 200-300
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特异性:
The antibody can specifically recognize human CD38 protein.
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基因名称:
CD38
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蛋白名称:
CD38
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别名:
ADP-ribosyl cyclase 1 ;
Cyclic ADP-ribose hydrolase 1 ;
cADPr hydrolase 1 ;
T10 ;
CD antigen CD38 ;
Cyclic ADP-ribose hydrolase 1 ;
cADPr hydrolase 1 ;
T10 ;
CD antigen CD38 ;
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背景:
The protein encoded by this gene is a non-lineage-restricted , type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose , an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail , a single membrane-spanning domain , and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer , with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Sep 2015] ,
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功能:
Catalytic activity:NAD (+) + H (2) O = ADP-ribose + nicotinamide. ,developmental stage:Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow , where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E. ,enzyme regulation:ATP inhibits the hydrolyzing activity. ,Function:Synthesizes cyclic ADP-ribose , a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. ,online information:CD38 entry ,similarity:Belongs to the ADP-ribosyl cyclase family. ,tissue specificity:Expressed at high levels in pancreas , liver , kidney , brain , testis , ovary , placenta , malignant lymphoma and neuroblastoma. ,
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细胞定位:
Membranous
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研究领域:
>>Nicotinate and nicotinamide metabolism ;
>>Metabolic pathways ;
>>Calcium signaling pathway ;
>>Hematopoietic cell lineage ;
>>Oxytocin signaling pathway ;
>>Salivary secretion ;
>>Pancreatic secretion
>>Metabolic pathways ;
>>Calcium signaling pathway ;
>>Hematopoietic cell lineage ;
>>Oxytocin signaling pathway ;
>>Salivary secretion ;
>>Pancreatic secretion
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信号通路
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货号: YM6840
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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