Function:Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin , calmodulin , troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. ,similarity:Belongs to the calponin family. ,similarity:Contains 1 CH (calponin-homology) domain. ,similarity:Contains 3 calponin-like repeats. ,subunit:Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin , CNN1/calponin H1 , PLN/phospholamban , PRKG1 and ITPR1. ,tissue specificity:Smooth muscle , and tissues containing significant amounts of smooth muscle. ,
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