Synthesized peptide derived from human CD14 AA range: 1-100

The antibody can specifically recognize human CD14 protein.

CD14

CD14

Monocyte differentiation antigen CD14 ;
Myeloid cell-specific leucine-rich glycoprotein ;
CD antigen CD14 ;
[Cleaved into: Monocyte differentiation antigen CD14,urinary form ;
Monocyte differentiation antigen CD14,membrane-bound form]

The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq , Mar 2010] ,

Function:Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) . Acts via MyD88 , TIRAP and TRAF6 , leading to NF-kappa-B activation , cytokine secretion and the inflammatory response. Up-regulates cell surface molecules , including adhesion molecules. ,online information:CD14 entry ,similarity:Contains 11 LRR (leucine-rich) repeats. ,subunit:Belongs to the lipopolysaccharide (LPS) receptor , a multi-protein complex containing at least CD14 , MD-2 and TLR4. ,tissue specificity:Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages. ,

Membranous , Cytoplasmic

>>MAPK signaling pathway ;
>>NF-kappa B signaling pathway ;
>>Phagosome ;
>>Toll-like receptor signaling pathway ;
>>Hematopoietic cell lineage ;
>>Alcoholic liver disease ;
>>Shigellosis ;
>>Salmonella infection ;
>>Pertussis ;
>>Legionellosis ;
>>Amoebiasis ;
>>Tuberculosis ;
>>Transcriptional misregulation in cancer ;
>>Acute myeloid leukemia ;
>>Lipid and atherosclerosis