Synthesized peptide derived from human GST-Pi AA range: 150-210

The antibody can specifically recognize human GST-Pi protein.

GSTP1 FAEES3 GST3

GST-Pi

Glutathione S-transferase P ;
GST class-pi ;
GSTP1-1 ;

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical , immunologic , and structural properties , the soluble GSTs are categorized into 4 main classes: alpha , mu , pi , and theta. This GST family member is a polymorphic gene encoding active , functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer , and other diseases. [provided by RefSeq , Jul 2008] ,

Catalytic activity:RX + glutathione = HX + R-S-glutathione. ,Function:Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. ,online information:The Singapore human mutation and polymorphism database ,similarity:Belongs to the GST superfamily. Pi family. ,similarity:Contains 1 GST C-terminal domain. ,similarity:Contains 1 GST N-terminal domain. ,subunit:Homodimer. ,

Cytoplasmic

>>Glutathione metabolism ;
>>Metabolism of xenobiotics by cytochrome P450 ;
>>Drug metabolism - cytochrome P450 ;
>>Drug metabolism - other enzymes ;
>>Metabolic pathways ;
>>Platinum drug resistance ;
>>Pathways in cancer ;
>>Chemical carcinogenesis - DNA adducts ;
>>Prostate cancer ;
>>Hepatocellular carcinoma ;
>>Fluid shear stress and atherosclerosis