developmental stage:Expressed at early B-cell differentiation , in the developing CNS and in adult testis. ,Disease:A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t (9;18) (p13;q11.2) with ZNF521. Translocation t (9;3) (p13;p14.1) with FOXP1. Translocation t (9;12) (p13;p13) with ETV6. ,Function:May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene , a B-lymphoid-specific target gene. ,PTM:O-glycosylated. ,similarity:Contains 1 paired domain. ,subunit:Interacts with DAXX (By similarity) . Binds DNA as a monomer. Binds TLE4. ,
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