Myeloperoxidase(MPO) (ABT-MPO) Mouse mAb (Ready to Use)
-YM6663R
主要信息
Target
MPO
Host Species
Mouse
Reactivity
Human
Applications
IHC
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
Ready to use for IHC
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
特异性
The antibody can specifically recognize human Myeloperoxidase protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
2°C to 8°C/1 year,Ship by ice bag
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT-MPO
同种型
IgG2a, Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human Myeloperoxidase(MPO) AA range: 350-450
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特异性:
The antibody can specifically recognize human Myeloperoxidase protein.
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基因名称:
MPO
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蛋白名称:
Myeloperoxidase (MPO)
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背景:
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor , myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq , Nov 2014] ,
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功能:
Catalytic activity:Cl (-) + H (2) O (2) = HOCl + 2 H (2) O. ,Catalytic activity:Donor + H (2) O (2) = oxidized donor + 2 H (2) O. ,cofactor:Binds 1 calcium ion per heterodimer. ,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer. ,Disease:Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis. ,Function:Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN , MPO catalyzes the production of hypohalous acids , primarily hypochlorous acid in physiologic situations , and other toxic intermediates that greatly enhance PMN microbicidal activity. ,online information:MPO mutation db ,online information:Myeloperoxidase entry ,similarity:Belongs to the peroxidase family. XPO subfamily. ,subunit:Tetramer of two light chains and two heavy chains. ,
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细胞定位:
Cytoplasmic
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组织表达:
研究领域:
>>Drug metabolism - other enzymes ;
>>Phagosome ;
>>Neutrophil extracellular trap formation ;
>>Transcriptional misregulation in cancer ;
>>Acute myeloid leukemia
>>Phagosome ;
>>Neutrophil extracellular trap formation ;
>>Transcriptional misregulation in cancer ;
>>Acute myeloid leukemia
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