Synthesized peptide derived from human IGF-2 AA range: 1-100

The antibody can specifically recognize human IGF-2 protein.

IGF2 PP1446

Insulin-like growth factor II (IGF-II) (Somatomedin-A) [Cleaved into: Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin]

This gene encodes a member of the insulin family of polypeptide growth factors , which are involved in development and growth. It is an imprinted gene , expressed only from the paternal allele , and epigenetic changes at this locus are associated with Wilms tumour , Beckwith-Wiedemann syndrome , rhabdomyosarcoma , and Silver-Russell syndrome. A read-through INS-IGF2 gene exists , whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Oct 2010] ,

Disease:Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730]. ,Function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides , amino acids and fatty acids. It accelerates glycolysis , the pentose phosphate cycle , and glycogen synthesis in liver. ,Function:Preptin undergoes glucose-mediated co-secretion with insulin , and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. ,Function:The insulin-like growth factors possess growth-promoting activity. In vitro , they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. ,mass spectrometry: PubMed:12586351; PubMed:15359740 ,online information:Clinical information on Eli Lilly insulin products ,online information:Insulin entry ,online information:Insulin-like growth factor 2 entry ,online information:Protein of the 20th century - Issue 9 of April 2001 ,pharmaceutical:Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk) . Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53. ,similarity:Belongs to the insulin family. ,subunit:Heterodimer of a B chain and an A chain linked by two disulfide bonds. ,

Cytoplasmic

>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>Hepatocellular carcinoma