CD279/PD1 (ABT-PD1) Mouse mAb
-YM6208
主要信息
Target
PD1
Host Species
Mouse
Reactivity
Human
Applications
IHC, IF, ELISA
MW
32kD (Calculated)
56kD (Observed)
Conjugate/Modification
Unmodified
货号: YM6208
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
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详细信息
推荐稀释比
IHC 1:200-400; IF 1:200-1:1000; ELISA 1:500-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
The antibody can specifically recognize human PD-1 protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
32kD
实测条带
56kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT-PD1
同种型
IgG1, Kappa
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CD279/PD1 (ABT-PD1) Mouse mAb (Ready to Use)
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human PD-1 AA range: 1-100
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特异性:
The antibody can specifically recognize human PD-1 protein.
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基因名称:
PDCD1 PD1
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蛋白名称:
Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
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背景:
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice , expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq , Jul 2008] ,
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功能:
developmental stage:Induced at programmed cell death. ,Disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic , inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin , joints , kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. ,Function:Possible cell death inducer , in association with other factors. ,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain. ,subunit:Monomer. ,
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细胞定位:
Membranous , Cytoplasmic
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组织表达:
研究领域:
>>Cell adhesion molecules ;
>>T cell receptor signaling pathway ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer
>>T cell receptor signaling pathway ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer
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信号通路
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货号: YM6208
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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