Claudin 18 (ABT158) Mouse mAb (Ready to Use)
-YM6183R
主要信息
Target
Claudin 18
Host Species
Mouse
Reactivity
Human
Applications
IHC
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
Ready to use for IHC
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
特异性
The antibody can specifically recognize both human Claudin 18.1 and Claudin 18.2 protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
2°C to 8°C/1 year,Ship by ice bag
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT158
同种型
IgG1, Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human Claudin 18 AA range: 150-261
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特异性:
The antibody can specifically recognize both human Claudin 18.1 and Claudin 18.2 protein.
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基因名称:
CLDN18 UNQ778/PRO1572
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蛋白名称:
Claudin 18
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别名:
Claudin-18
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背景:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets , and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq , Jun 2010] ,
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功能:
Function:Plays a major role in tight junction-specific obliteration of the intercellular space , through calcium-independent cell-adhesion activity. ,similarity:Belongs to the claudin family. ,tissue specificity:Concentrated at the cell-cell borders of epithelial cells. ,
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细胞定位:
Membranous
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研究领域:
>>Cell adhesion molecules ;
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Pathogenic Escherichia coli infection ;
>>Hepatitis C
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Pathogenic Escherichia coli infection ;
>>Hepatitis C
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