Fascin (ABT-FASN) Mouse mAb
-YM6178
主要信息
Target
Fascin
Host Species
Mouse
Reactivity
Human, Mouse, Rat
Applications
IHC, ELISA
MW
55kD (Calculated)
55kD (Observed)
Conjugate/Modification
Unmodified
货号: YM6178
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
IHC 1:200-400; ELISA 1:500-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
The antibody can specifically recognize human Fascin protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
55kD
实测条带
55kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT-FASN
同种型
IgG1, Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human Fascin AA range: 250-350
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特异性:
The antibody can specifically recognize human Fascin protein.
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基因名称:
FSCN1 FAN1 HSN SNL
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蛋白名称:
Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55)
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背景:
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles , and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration , motility , adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs , and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq , Sep 2011] ,
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功能:
Disease:Marks and mediates breast cancer metastasis to the lungs. FSCN1 is not functionally validated but achieves the highest statistical significance (P less than 0.000001) . Those subjects expressing the lung metastasis signature have a significantly poorer lung metastasis-free survival , but not bone metastasis-free survival , compared to subjects without the signature. ,Function:Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Probably involved in the assembly of actin filament bundles present in microspikes , membrane ruffles , and stress fibers. ,PTM:Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin. ,similarity:Belongs to the fascin family. ,subunit:Associates with beta-catenin. ,tissue specificity:Ubiquitous. ,
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细胞定位:
Cytoplasmic
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组织表达:
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研究领域:
>>MicroRNAs in cancer
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文献引用（{{totalcount}}）
货号: YM6178
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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