CD68 (ABT-CD68) Mouse mAb (Ready to Use)
-YM6022R
主要信息
Target
CD68
Host Species
Mouse
Reactivity
Human
Applications
IHC
Conjugate/Modification
Unmodified
详细信息
推荐稀释比
Ready to use for IHC
组成
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
特异性
The antibody can specifically recognize human CD68 protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
2°C to 8°C/1 year,Ship by ice bag
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT-CD68
同种型
IgG1, Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human CD68 AA range: 250-354
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特异性:
The antibody can specifically recognize human CD68 protein.
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基因名称:
CD68
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蛋白名称:
Macrosialin (Gp110) (CD antigen CD68)
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背景:
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris , promote phagocytosis , and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq , Jul 2008] ,
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功能:
Function:Could play a role in phagocytic activities of tissue macrophages , both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Bind to tissue- and organ-specific lectins or selectins , allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes , lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells. ,PTM:N- and O-glycosylated. ,similarity:Belongs to the LAMP family. ,tissue specificity:Highly expressed by blood monocytes and tissue macrophages. Also expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium , facilitating their dissemination to secondary sites. ,
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细胞定位:
Cytoplasmic , Membranous
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研究领域:
>>Lysosome
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