Cyclin B1 (1A5) Mouse mAb
-YM3650
主要信息
Target
Cyclin B1
Host Species
Mouse
Reactivity
Human, Mouse, Rat
Applications
IHC, IF
MW
55kD (Observed)
Conjugate/Modification
Unmodified
货号: YM3650
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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详细信息
推荐稀释比
IHC 1:100-200; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Cyclin B1 protein detects endogenous levels of CCNB1
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
55kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
1A5
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抗原&靶点信息
免疫原:
Synthetic Peptide of Cyclin B1 at AA range of 60-140
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特异性:
Cyclin B1 protein detects endogenous levels of CCNB1
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基因名称:
CCNB1 CCNB
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蛋白名称:
G2/mitotic-specific cyclin-B1
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别名:
CCNB1 ;
CCNB ;
G2/mitotic-specific cyclin-B1
CCNB ;
G2/mitotic-specific cyclin-B1
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背景:
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008],
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功能:
developmental stage:Accumulates steadily during G2 and is abruptly destroyed at mitosis.,Function:Essential for the control of the cell cycle at the G2/M (mitosis) transition.,PTM:Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin AB subfamily.,subunit:Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase.,
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细胞定位:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
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组织表达:
研究领域:
>>FoxO signaling pathway ;
>>Cell cycle ;
>>Oocyte meiosis ;
>>p53 signaling pathway ;
>>Cellular senescence ;
>>Progesterone-mediated oocyte maturation ;
>>Human immunodeficiency virus 1 infection
>>Cell cycle ;
>>Oocyte meiosis ;
>>p53 signaling pathway ;
>>Cellular senescence ;
>>Progesterone-mediated oocyte maturation ;
>>Human immunodeficiency virus 1 infection
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信号通路
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货号: YM3650
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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