CD68 (6F3) Mouse mAb
-YM3050
主要信息
Target
CD68
Host Species
Mouse
Reactivity
Human, Mouse, Rat
Applications
IHC, IF
MW
37kD (Observed)
Conjugate/Modification
Unmodified
货号: YM3050
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
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详细信息
推荐稀释比
IHC 1:200-400; IF 1:50-200
组成
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
特异性
The antibody detects endogenous CD68 proteins.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
实测条带
37kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
6F3
同种型
IgG2b, Kappa
RRID号
AB_2923241
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抗原&靶点信息
免疫原:
Synthetic Peptide of CD68
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特异性:
The antibody detects endogenous CD68 proteins.
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基因名称:
CD68
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蛋白名称:
Macrosialin
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别名:
CD68 ;
Macrosialin ;
Gp110 ;
CD68
Macrosialin ;
Gp110 ;
CD68
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背景:
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris , promote phagocytosis , and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq , Jul 2008] ,
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功能:
Function:Could play a role in phagocytic activities of tissue macrophages , both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Bind to tissue- and organ-specific lectins or selectins , allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes , lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells. ,PTM:N- and O-glycosylated. ,similarity:Belongs to the LAMP family. ,tissue specificity:Highly expressed by blood monocytes and tissue macrophages. Also expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium , facilitating their dissemination to secondary sites. ,
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细胞定位:
[Isoform Short]: Cell membrane; Single-pass type I membrane protein.; [Isoform Long]: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
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研究领域:
>>Lysosome
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货号: YM3050
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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