Synthesized peptide derived from human protein.AA range: 1-100

This antibody detects endogenous levels of β-actin protein.

ACTB

Actin cytoplasmic 1

ACTB ;
Actin ;
cytoplasmic 1 ;
Beta-actin ;
Actin β ;
β-Actin ;
Beta actin ;
B actin ;
actin Beta ;

This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility , structure , and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq , Jul 2008] ,

Disease:Defects in ACTB are a cause of dystonia juvenile-onset (DYTJ) [MIM:607371]. DYTJ is a form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction , often leading to abnormal postures. DYTJ patients manifest progressive , generalized , dopa-unresponsive dystonia , developmental malformations and sensory hearing loss. ,Function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. ,miscellaneous:In vertebrates 3 main groups of actin isoforms , alpha , beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. ,similarity:Belongs to the actin family. ,subunit:Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Component of the BAF complex , which includes at least actin (ACTB) , ARID1A , ARID1B/BAF250 , SMARCA2 , SMARCA4/BRG1 , ACTL6A/BAF53 , ACTL6B/BAF53B , SMARCE1/BAF57 SMARCC1/BAF155 , SMARCC2/BAF170 , SMARCB1/SNF5/INI1 , and one or more of SMARCD1/BAF60A , SMARCD2/BAF60B , or SMARCD3/BAF60C. In muscle cells , the BAF complex also contains DPF3. Found in a complex with XPO6 , Ran , ACTB and PFN1. Interacts with XPO6. ,

Cytoplasmic

>>Rap1 signaling pathway ;
>>Phagosome ;
>>Apoptosis ;
>>Hippo signaling pathway ;
>>Focal adhesion ;
>>Adherens junction ;
>>Tight junction ;
>>Platelet activation ;
>>Neutrophil extracellular trap formation ;
>>Leukocyte transendothelial migration ;
>>Thermogenesis ;
>>Regulation of actin cytoskeleton ;
>>Thyroid hormone signaling pathway ;
>>Oxytocin signaling pathway ;
>>Gastric acid secretion ;
>>Amyotrophic lateral sclerosis ;
>>Bacterial invasion of epithelial cells ;
>>Vibrio cholerae infection ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Salmonella infection ;
>>Yersinia infection ;
>>Influenza A ;
>>Proteoglycans in cancer ;
>>Hepatocellular carcinoma ;
>>Hypertrophic cardiomyopathy ;
>>Arrhythmogenic right ventricular cardiomyopathy ;
>>Dilated cardiomyopathy ;
>>Viral myocarditis ;
>>Fluid shear stress and atherosclerosis