CHD4 Mouse mAb
-YM1353
主要信息
Target
CHD4
Host Species
Mouse
Reactivity
Human
Applications
WB, CoIP
MW
260kD (Observed)
Conjugate/Modification
Unmodified
货号: YM1353
规格
价格
货期
数量
200μL
￥3,780.00
一周
0
100μL
￥2,300.00
一周
0
40μL
￥960.00
一周
0
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详细信息
推荐稀释比
WB 1:1000; IP 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of CHD4 and does not cross-react with related proteins.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
实测条带
260kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
8B8
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抗原&靶点信息
免疫原:
Purified recombinant human CHD4 protein fragments expressed in E.coli.
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特异性:
This antibody detects endogenous levels of CHD4 and does not cross-react with related proteins.
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基因名称:
CHD4
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别名:
CHD4 ;
Chromodomain-helicase-DNA-binding protein 4 ;
CHD-4 ;
ATP-dependent helicase CHD4 ;
Mi-2 autoantigen 218 kDa protein ;
Mi2-beta
Chromodomain-helicase-DNA-binding protein 4 ;
CHD-4 ;
ATP-dependent helicase CHD4 ;
Mi-2 autoantigen 218 kDa protein ;
Mi2-beta
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背景:
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014],
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功能:
Disease:One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.,Function:Probable transcription regulator.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 2 chromo domains.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex. Interacts with TRIM27. Part of a complex containing ATR and HDAC2. Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression.,
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细胞定位:
Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with centrosomes in interphase. .
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组织表达:
研究领域:
>>Human papillomavirus infection ;
>>Viral carcinogenesis
>>Viral carcinogenesis
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文献引用（{{totalcount}}）
货号: YM1353
规格
价格
货期
数量
200μL
￥3,780.00
一周
0
100μL
￥2,300.00
一周
0
40μL
￥960.00
一周
0
加入购物车
已收藏
收藏
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