Purified recombinant human HXK II (N-terminus) protein fragments expressed in E.coli.

HXK II Monoclonal Antibody detects endogenous levels of HXK II protein.

HK2

Hexokinase-2

HK2 ;
Hexokinase-2 ;
Hexokinase type II ;
HK II ;
Muscle form hexokinase

Hexokinases phosphorylate glucose to produce glucose-6-phosphate , the first step in most glucose metabolism pathways. This gene encodes hexokinase 2 , the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive , and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq , Apr 2009] ,

Catalytic activity:ATP + D-hexose = ADP + D-hexose 6-phosphate. ,Domain:The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. ,enzyme regulation:Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P. ,miscellaneous:In vertebrates there are four major glucose-phosphorylating isoenzymes , designated hexokinase I , II , III and IV (glucokinase) . ,online information:Hexokinase entry ,pathway:Carbohydrate metabolism; hexose metabolism. ,polymorphism:Although found in NIDDM patients , genetic variations of HK2 do not contribute to the disease. ,similarity:Belongs to the hexokinase family. ,subcellular location:Its hydrophobic N-terminal sequence may be involved in membrane binding. ,subunit:Monomer. ,tissue specificity:Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. ,

Mitochondrion outer membrane ; Peripheral membrane protein . Cytoplasm , cytosol . The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880) . The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein (PubMed:29298880) . Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis (PubMed:18350175) . .

>>Glycolysis / Gluconeogenesis ;
>>Fructose and mannose metabolism ;
>>Galactose metabolism ;
>>Starch and sucrose metabolism ;
>>Amino sugar and nucleotide sugar metabolism ;
>>Neomycin , kanamycin and gentamicin biosynthesis ;
>>Metabolic pathways ;
>>Carbon metabolism ;
>>Biosynthesis of nucleotide sugars ;
>>HIF-1 signaling pathway ;
>>Insulin signaling pathway ;
>>Type II diabetes mellitus ;
>>Carbohydrate digestion and absorption ;
>>Shigellosis ;
>>Central carbon metabolism in cancer