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RSK2 Mouse mAb

-YM0565

2 5
主要信息
Target

RSK2

Host Species

Mouse

Reactivity

Human

Applications

WB, IF, FC, ELISA

MW

84kD (Calculated)

Conjugate/Modification

Unmodified

货号: YM0565
规格
价格
货期
数量
200μL
¥5,880.00
一周

0

100μL
¥3,200.00
一周

0

50μL
¥2,000.00
一周

0

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详细信息
推荐稀释比
WB 1:500-1:2000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Rsk-2 Monoclonal Antibody detects endogenous levels of Rsk-2 protein.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
84kD
修饰
Unmodified
克隆性
Monoclonal
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抗原&靶点信息
免疫原:
Purified recombinant fragment of human Rsk-2 expressed in E. Coli.
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特异性:
Rsk-2 Monoclonal Antibody detects endogenous levels of Rsk-2 protein.
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基因名称:
RPS6KA3 ISPK1 MAPKAPK1B RSK2
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蛋白名称:
Ribosomal protein S6 kinase alpha-3
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别名:
RPS6KA3 ;
ISPK1 ;
MAPKAPK1B ;
RSK2 ;
Ribosomal protein S6 kinase alpha-3 ;
S6K-alpha-3 ;
90 kDa ribosomal protein S6 kinase 3 ;
p90-RSK 3 ;
p90RSK3 ;
Insulin-stimulated protein kinase 1 ;
ISPK-1 ;
MAP kinase-activated protein kinase 1b ;
MAPK-activated
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数据库链接:
Organism 基因 ID SwissProt
Human 6197; P51812;
Mouse 110651; P18654;
背景:
ribosomal protein S6 kinase A3(RPS6KA3) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008],
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,Disease:Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,Function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-386, as part of the activation process.,PTM:Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity). Interacts with NFATC4.,tissue specificity:Expressed in many tissues, highest levels in skeletal muscle.,
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细胞定位:
Nucleus . Cytoplasm .
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组织表达:
Expressed in many tissues, highest levels in skeletal muscle.
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研究领域:
>>MAPK signaling pathway ;
>>Oocyte meiosis ;
>>mTOR signaling pathway ;
>>Thermogenesis ;
>>Long-term potentiation ;
>>Neurotrophin signaling pathway ;
>>Progesterone-mediated oocyte maturation ;
>>Insulin resistance ;
>>Yersinia infection ;
>>Chemical carcinogenesis - receptor activation
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货号: YM0565
规格
价格
货期
数量
200μL
¥5,880.00
一周

0

100μL
¥3,200.00
一周

0

50μL
¥2,000.00
一周

0

加入购物车

已收藏

收藏

定制服务咨询

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