Pinch-1 Mouse mAb
-YM0520
主要信息
Target
Pinch-1
Host Species
Mouse
Reactivity
Human
Applications
WB, IF, FC, ELISA
MW
37kD (Calculated)
Conjugate/Modification
Unmodified
货号: YM0520
规格
价格
货期
数量
200μL
￥5,880.00
一周
0
100μL
￥3,200.00
一周
0
50μL
￥2,000.00
一周
0
加入购物车
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详细信息
推荐稀释比
WB 1:500-1:2000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Pinch-1 Monoclonal Antibody detects endogenous levels of Pinch-1 protein.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
37kD
修饰
Unmodified
克隆性
Monoclonal
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抗原&靶点信息
免疫原:
Purified recombinant fragment of human Pinch-1 expressed in E. Coli.
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特异性:
Pinch-1 Monoclonal Antibody detects endogenous levels of Pinch-1 protein.
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基因名称:
LIMS1
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蛋白名称:
LIM and senescent cell antigen-like-containing domain protein 1
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别名:
LIMS1 ;
PINCH ;
PINCH1 ;
LIM and senescent cell antigen-like-containing domain protein 1 ;
Particularly interesting new Cys-His protein 1 ;
PINCH-1 ;
Renal carcinoma antigen NY-REN-48
PINCH ;
PINCH1 ;
LIM and senescent cell antigen-like-containing domain protein 1 ;
Particularly interesting new Cys-His protein 1 ;
PINCH-1 ;
Renal carcinoma antigen NY-REN-48
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背景:
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010],
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功能:
Function:Effector of integrin and growth factor signaling, coupling surface receptors to downstream signaling molecules involved in the regulation of cell survival, cell proliferation and cell differentiation. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway.,similarity:Contains 5 LIM zinc-binding domains.,subunit:Interacts (via LIM zinc-binding 5) with TGFB1I1 (By similarity). Interacts (via LIM zinc-binding 1) with ILK. Interacts with SH3/SH2 adapter NCK2.,tissue specificity:In most tissues, except in the brain.,
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细胞定位:
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
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组织表达:
Expressed in most tissues except in the brain.
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货号: YM0520
规格
价格
货期
数量
200μL
￥5,880.00
一周
0
100μL
￥3,200.00
一周
0
50μL
￥2,000.00
一周
0
加入购物车
已收藏
收藏
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