Purified recombinant fragment of human Mi2-α expressed in E. Coli.

Mi2-α Monoclonal Antibody detects endogenous levels of Mi2-α protein.

CHD3

Chromodomain-helicase-DNA-binding protein 3

CHD3 ;
Chromodomain-helicase-DNA-binding protein 3 ;
CHD-3 ;
ATP-dependent helicase CHD3 ;
Mi-2 autoantigen 240 kDa protein ;
Mi2-alpha ;
Zinc finger helicase ;
hZFH

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008],

Disease:One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.,Function:Probable transcription regulator.,sequence Caution:Differs from position 1967 onward for unknown reasons.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 2 chromo domains.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressive complex. Interacts with TRIM28 and SERBP1. Interacts via its C-terminal region with HABP4.,tissue specificity:Widely expressed.,

Nucleus, PML body . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with centrosomes in interphase and mitosis. .

Widely expressed.