Fes Mouse mAb
-YM0263
主要信息
Target
Fes
Host Species
Mouse
Reactivity
Human
Applications
WB, IHC, IF, ELISA
MW
93kD (Calculated)
Conjugate/Modification
Unmodified
货号: YM0263
规格
价格
货期
数量
200μL
￥5,880.00
一周
0
100μL
￥3,200.00
一周
0
50μL
￥2,000.00
一周
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Fes Monoclonal Antibody detects endogenous levels of Fes protein.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
93kD
修饰
Unmodified
克隆性
Monoclonal
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抗原&靶点信息
免疫原:
Purified recombinant fragment of Fer expressed in E. Coli.
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特异性:
Fes Monoclonal Antibody detects endogenous levels of Fes protein.
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基因名称:
FES FPS
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蛋白名称:
Tyrosine-protein kinase Fes/Fps
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别名:
FES ;
FPS ;
Tyrosine-protein kinase Fes/Fps ;
Feline sarcoma/Fujinami avian sarcoma oncogene homolog ;
Proto-oncogene c-Fes ;
Proto-oncogene c-Fps ;
p93c-fes
FPS ;
Tyrosine-protein kinase Fes/Fps ;
Feline sarcoma/Fujinami avian sarcoma oncogene homolog ;
Proto-oncogene c-Fes ;
Proto-oncogene c-Fps ;
p93c-fes
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背景:
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009],
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功能:
Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.,similarity:Contains 1 FCH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,
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细胞定位:
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery.
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组织表达:
Widely expressed. Detected in adult colon epithelium (at protein level) (PubMed:16455651, PubMed:19051325). Expressed in melanocytes (at protein level) (PubMed:28463229).
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研究领域:
>>Axon guidance
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货号: YM0263
规格
价格
货期
数量
200μL
￥5,880.00
一周
0
100μL
￥3,200.00
一周
0
50μL
￥2,000.00
一周
0
加入购物车
已收藏
收藏
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