ETS1 Mouse mAb
-YM0255
主要信息
Target
ETS1
Host Species
Mouse
Reactivity
Human
Applications
WB, IHC, IF, FC, ELISA
MW
50kD (Calculated)
Conjugate/Modification
Unmodified
货号: YM0255
规格
价格
货期
数量
200μL
￥5,880.00
一周
0
100μL
￥3,200.00
一周
0
50μL
￥2,000.00
一周
0
加入购物车
已收藏
收藏
详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
ETS1 Monoclonal Antibody detects endogenous levels of ETS1 protein.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
50kD
修饰
Unmodified
克隆性
Monoclonal
相关产品
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
预览→
Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
预览→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
预览→
Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
预览→
抗原&靶点信息
免疫原:
Purified recombinant fragment of human ETS1 expressed in E. Coli.
展开内容
特异性:
ETS1 Monoclonal Antibody detects endogenous levels of ETS1 protein.
展开内容
基因名称:
ETS1
展开内容
蛋白名称:
Protein C-ets-1
展开内容
别名:
Ets-1 ;
ETS1 ;
EWSR2 ;
Protein C-ets-1 ;
p54
ETS1 ;
EWSR2 ;
Protein C-ets-1 ;
p54
展开内容
背景:
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011],
展开内容
功能:
Disease:ETS is responsible for erythroblast and fibroblast transformation. The juxtaposition of the interferon and c-ETS-1 proto-oncogene may be involved in the pathogenesis of human monocytic leukemia.,Function:Transcription factor.,PTM:Sumoylated on Lys-15 and Lys-227, preferentially by SUMO2; which inhibits transcriptional activity.,PTM:Ubiquitinated; which induces proteasomal degradation.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,similarity:Contains 1 PNT (pointed) domain.,subunit:Interacts with MAF and MAFB (By similarity). Binds to DAXX. Interacts with UBE2I.,
展开内容
细胞定位:
Cytoplasm . Nucleus . Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. .
展开内容
组织表达:
Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.
展开内容
研究领域:
>>Ras signaling pathway ;
>>Cellular senescence ;
>>Human T-cell leukemia virus 1 infection ;
>>Pathways in cancer ;
>>Renal cell carcinoma
>>Cellular senescence ;
>>Human T-cell leukemia virus 1 infection ;
>>Pathways in cancer ;
>>Renal cell carcinoma
展开内容
信号通路
文献引用（{{totalcount}}）
货号: YM0255
规格
价格
货期
数量
200μL
￥5,880.00
一周
0
100μL
￥3,200.00
一周
0
50μL
￥2,000.00
一周
0
加入购物车
已收藏
收藏
Recently Viewed Products
Clear all
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
主要信息
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
产品 {{index}}/{{pcount}}
上一个产品
下一个产品
{{pvTitle}}
滚轮缩放图片
{{pvDescr}}