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EphB1 Mouse mAb

-YM0229

2 5
主要信息
Target

EphB1

Host Species

Mouse

Reactivity

Human

Applications

WB, IHC, IF, ELISA

MW

110kD (Calculated)

Conjugate/Modification

Unmodified

货号: YM0229
规格
价格
货期
数量
200μL
¥5,880.00
一周

0

100μL
¥3,200.00
一周

0

50μL
¥2,000.00
一周

0

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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
EphB1 Monoclonal Antibody detects endogenous levels of EphB1 protein.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
110kD
修饰
Unmodified
克隆性
Monoclonal
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抗原&靶点信息
免疫原:
Purified recombinant fragment of EphB1 (aa19-133) expressed in E. Coli.
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特异性:
EphB1 Monoclonal Antibody detects endogenous levels of EphB1 protein.
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基因名称:
EPHB1
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蛋白名称:
Ephrin type-B receptor 1
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别名:
EPHB1 ;
ELK ;
EPHT2 ;
HEK6 ;
NET ;
Ephrin type-B receptor 1 ;
ELK ;
EPH tyrosine kinase 2 ;
EPH-like kinase 6 ;
EK6 ;
hEK6 ;
Neuronally-expressed EPH-related tyrosine kinase ;
NET ;
Tyrosine-protein kinase receptor EPH-2
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数据库链接:
Organism 基因 ID SwissProt
Human 2047; P54762;
Mouse Q8CBF3;
背景:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008],
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功能:
Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Function:Receptor for members of the ephrin-B family. Binds to ephrin-B1, -B2 and -B3. May be involved in cell-cell interactions in the nervous system.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:The ligand-activated form interacts with GRB2, GRB10 and NCK through their respective SH2 domains. The GRB10 SH2 domain binds EPHB1 through Tyr-928, while GRB2 binds residues within the catalytic domain. Interacts with EPHB6. The NCK SH2 domain binds EPHB1 through Tyr-594. Interacts with PRKCABP.,tissue specificity:Preferentially expressed in brain.,
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细胞定位:
Cell membrane ; Single-pass type I membrane protein . Early endosome membrane . Cell projection, dendrite .
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组织表达:
Preferentially expressed in brain.
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研究领域:
>>Axon guidance
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货号: YM0229
规格
价格
货期
数量
200μL
¥5,880.00
一周

0

100μL
¥3,200.00
一周

0

50μL
¥2,000.00
一周

0

加入购物车

已收藏

收藏

定制服务咨询

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