Csk Mouse mAb
-YM0170
主要信息
Target
Csk
Host Species
Mouse
Reactivity
Human, Mouse, Rat, Monkey
Applications
WB, IF, FC, ELISA
MW
51kD (Calculated)
Conjugate/Modification
Unmodified
货号: YM0170
规格
价格
货期
数量
200μL
￥5,880.00
一周
0
100μL
￥3,200.00
一周
0
50μL
￥2,000.00
一周
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Csk Monoclonal Antibody detects endogenous levels of Csk protein.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
51kD
修饰
Unmodified
克隆性
Monoclonal
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抗原&靶点信息
免疫原:
Purified recombinant fragment of human Csk expressed in E. Coli.
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特异性:
Csk Monoclonal Antibody detects endogenous levels of Csk protein.
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基因名称:
CSK
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蛋白名称:
Tyrosine-protein kinase CSK
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别名:
CSK ;
Tyrosine-protein kinase CSK ;
C-Src kinase ;
Protein-tyrosine kinase CYL
Tyrosine-protein kinase CSK ;
C-Src kinase ;
Protein-tyrosine kinase CYL
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背景:
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly cytoplasmic, also present in lipid rafts.,subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.,tissue specificity:Expressed in lung and macrophages.,
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功能:
Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly cytoplasmic, also present in lipid rafts.,subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.,tissue specificity:Expressed in lung and macrophages.,
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细胞定位:
Cytoplasm . Cell membrane . Mainly cytoplasmic, also present in lipid rafts. .
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组织表达:
Expressed in lung and macrophages.
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研究领域:
>>Epithelial cell signaling in Helicobacter pylori infection
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货号: YM0170
规格
价格
货期
数量
200μL
￥5,880.00
一周
0
100μL
￥3,200.00
一周
0
50μL
￥2,000.00
一周
0
加入购物车
已收藏
收藏
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