Cleaved Cathepsin B (Leu80) Rabbit pAb
-YC0120
主要信息
Target
Cathepsin B
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
28kD,37kD (Observed)
Conjugate/Modification
Unmodified
货号: YC0120
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
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详细信息
推荐稀释比
WB 1:1000-2000; ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of Human CATB (Cleaved-Leu80, protein was cleaved amino acid sequence between 79-80)
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
28kD,37kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human CATB (Cleaved-Leu80)
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特异性:
This antibody detects endogenous levels of Human CATB (Cleaved-Leu80, protein was cleaved amino acid sequence between 79-80)
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基因名称:
CTSB CPSB
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蛋白名称:
CATB (Cleaved-Leu80)
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别名:
CTSB ;
CPSB ;
Cathepsin B ;
APP secretase ;
APPS ;
Cathepsin B1 ;
[Cleaved into: Cathepsin B light chain ;
Cathepsin B heavy chain]
CPSB ;
Cathepsin B ;
APP secretase ;
APPS ;
Cathepsin B1 ;
[Cleaved into: Cathepsin B light chain ;
Cathepsin B heavy chain]
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背景:
catalytic activity:Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.,function:Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.,similarity:Belongs to the peptidase C1 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.,
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功能:
proteolysis, response to wounding, regulation of cell death, regulation of apoptosis, regulation of programmed cell death,
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细胞定位:
Lysosome . Melanosome . Secreted, extracellular space . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity). .
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研究领域:
>>Autophagy - animal ;
>>Lysosome ;
>>Apoptosis ;
>>Antigen processing and presentation ;
>>NOD-like receptor signaling pathway ;
>>Renin secretion
>>Lysosome ;
>>Apoptosis ;
>>Antigen processing and presentation ;
>>NOD-like receptor signaling pathway ;
>>Renin secretion
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信号通路
Cellular Processes >> Transport and catabolism >> Lysosome
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Cellular Processes >> Cell growth and death >> Apoptosis
Organismal Systems >> Immune system >> NOD-like receptor signaling pathway
Organismal Systems >> Immune system >> Antigen processing and presentation
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货号: YC0120
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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