Cleaved Caspase-4 p20 (Gln81) Rabbit pAb
-YC0028
主要信息
Target
Caspase-4
Host Species
Rabbit
Reactivity
Human
Applications
WB, IHC, IF, ELISA
MW
43kD,22kD (Observed)
Conjugate/Modification
Unmodified
货号: YC0028
规格
价格
货期
数量
200μL
￥3,780.00
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0
100μL
￥2,300.00
现货
0
40μL
￥960.00
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0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Cleaved-Caspase-4 p20 (Q81) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-4 p20 protein resulting from cleavage adjacent to Q81.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
43kD,22kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
RRID号
AB_3662999
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human Caspase 4. AA range:62-111
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特异性:
Cleaved-Caspase-4 p20 (Q81) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-4 p20 protein resulting from cleavage adjacent to Q81.
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基因名称:
CASP4 ICH2
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蛋白名称:
Caspase4
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别名:
CASP4 ;
ICH2 ;
Caspase-4 ;
CASP-4 ;
ICE ;
rel ;
-II ;
Protease ICH-2 ;
Protease TX
ICH2 ;
Caspase-4 ;
CASP-4 ;
ICE ;
rel ;
-II ;
Protease ICH-2 ;
Protease TX
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背景:
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],
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功能:
Catalytic activity:Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.,Function:Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.,PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 1 CARD domain.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit.,tissue specificity:Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.,
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细胞定位:
Cytoplasm, cytosol . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Mitochondrion . Inflammasome . Secreted . Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 (PubMed:15123740). Released in the extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630). .
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研究领域:
>>Neutrophil extracellular trap formation ;
>>NOD-like receptor signaling pathway ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Salmonella infection
>>NOD-like receptor signaling pathway ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Salmonella infection
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信号通路
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货号: YC0028
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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